1. Role of serum fibronectin, serum d-dimer and other coagulation parameter levels in the diagnosis and prediction of severity in acute pancreatitis. We have studied 90 patients with acute pancreatitis and serially followed them with serum analysis for these markers during in hospital stay. We have correlated these markers with various clinical parameters and events occurring in acute pancreatitis. We intend to analyze their serum NFKB, TNF-alpha, IL levels and study the cytokine storm pattern occurring in acute pancreatitis.
    2. Effect of N-Acetyl Cysteine, Collagenase, Papain/Urea, Fibrinolysin and Streptokinase on pancreatic necrosis and blood vessels in vitro. We are studying the effect of these proteolytic and mucolytic agents on pancreatic necrotic tissue. This in-vitro study findings could supplement the ongoing treatment options for percutaneous drainage in walled off pancreatic necrosis which is currently being managed with surgery. This study is in the completion phase and awaiting pathological confirmation of our observations.
    3. Low Molecular Weight Heparin in the Treatment of Severe Acute Pancreatitis A Single Centre Open Labeled Prospective Randomized Controlled Trial. Based on our previous research findings of D-Dimer levels in acute pancreatitis, our postulations that giving heparin could prevent complications and organ failure by preserving the pancreatic microcirculation. This study is going on in PGIMER, Chandigarh and presently being planned to be made a multi centre trial.

Proposed research topics under ethical review:

    1. Role of mesenchymal stem cell transplantation in the outcome of a rat model of acute severe pancreatitis
    2. Role of steroid injections in refractory esophageal and pyloric strcitures. A randomized controlled trail.